Potassium Channel

KcsA

Potassium Channel

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Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (743)
Antibodies (5)

By Effects:	Controls (4) Inhibitors (478) Agonists (10) Antagonists (30) Activators (146) Modulators (25) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-161104

Kv2.1-IN-1	Inhibitor	98.64%
Kv2.1-IN-1 (compound 80) is a potent inhibitor of Kv2.1, with the IC₅₀ value of 0.07 μM, selectivity >130 fold over other K⁺, Na⁺, and Ca²⁺ ion channels.

HY-N3463

Isopimaric acid	Activator	≥99.0%
Isopimaric acid is a potent opener of large conductance calcium activated K⁺ (BK) channels.

HY-151891

TASK-1-IN-1	Inhibitor	98.36%
TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects.

HY-148304

VU6036720	Inhibitor	99.88%
VU6036720 is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 can inhibit Kir4.1/5.1 channels with an IC₅₀ value of 0.24 μM. VU6036720 can be used for the research of brain and kidney.

HY-W010950A

Flecainide hydrochloride	Inhibitor	98.02%
Flecainide hydrochloride is a potent and orally active antiarrhythmic agent. Flecainide hydrochloride blocks the cardiac fast inward Na⁺ current (INa) and the rapid component of the delayed rectifier K⁺ current. Flecainide hydrochloride prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide hydrochloride has the potential for the research of fetal tachycardias.

HY-P1422

Spadin	Inhibitor	99.08%
Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC₅₀ value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research.

HY-137563

A2793	Inhibitor	98.50%
A2793 is an efficient dual TWIK-related acid-sensitive K⁺ channel (TASK)-1/TRESK inhibitor, with an IC₅₀ of 6.8 μM for mTRESK. A2764 is more selective for TRESK, and it only moderately influences TREK-1 and TALK-1.

HY-B0252S

Hydrochlorothiazid-d₂	Activator	98.89%
Hydrochlorothiazid-d₂ is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

HY-P1440

BeKm-1	Inhibitor	99.51%
BeKm-1 is a HERG (human ether-a-go-go-related gene) blocking compound. BeKm-1 can be used for the research of heart disease.

HY-N2877

Annonacin	Inhibitor
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways.

HY-103308

TRAM-39	Inhibitor	99.66%
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IK_Ca) channels. TRAM-39 inhibits KCa3.1 channel with an IC₅₀ value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease.

HY-N2338

Cholesterol myristate		≥98.0%
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.

HY-135809

A2764 dihydrochloride	Inhibitor	99.05%
A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K⁺ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC₅₀=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception.

HY-108590

DMP-543	Inhibitor	99.96%
DMP-543 (XR-543) is a K_V7 channel blocker, also acts as a potent neurotransmitter release enhancer.

HY-17412R

Minocycline (hydrochloride) (Standard)	Activator
Minocycline (hydrochloride) (Standard) is the analytical standard of Minocycline (hydrochloride). This product is intended for research and analytical applications. Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.

HY-12082A

GSK369796 Dihydrochloride	Inhibitor	99.56%
GSK369796 Dihydrochloride is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC₅₀ of 7.5 μM.

HY-A0135

Enflurane	Inhibitor	≥98.0%
Enflurane, a volatile anaesthetic, is a potent inhibitor of high conductance Ca²⁺-activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by headspace gas chromatography-mass spectrometry.

HY-108595

VU590	Inhibitor
VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC₅₀ of 290 nM. VU590 also inhibits Kir7.1, with an IC₅₀ of 8 μM. VU590 is not a good probe of ROMK function in the kidney.

HY-17437

Mefloquine	Antagonist	99.96%
Mefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K⁺ channel (KvQT1/minK) antagonist with an IC₅₀ of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research.

HY-17001A

Flupirtine	Activator	99.98%
Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (743)

Antibodies (5)

Potassium Channel Related Products (743):